ID:CASP6_HUMAN DESCRIPTION: RecName: Full=Caspase-6; Short=CASP-6; EC=3.4.22.59; AltName: Full=Apoptotic protease Mch-2; Contains: RecName: Full=Caspase-6 subunit p18; Contains: RecName: Full=Caspase-6 subunit p11; Flags: Precursor; FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. CATALYTIC ACTIVITY: Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-. ENZYME REGULATION: Activation is suppressed by phosphorylation at Ser-257. SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. INTERACTION: Q01826:SATB1; NbExp=2; IntAct=EBI-718729, EBI-743747; SUBCELLULAR LOCATION: Cytoplasm. PTM: Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits. SIMILARITY: Belongs to the peptidase C14A family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp6/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55212
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
U20537 - Human cysteine protease Mch2 isoform beta (Mch2) mRNA, complete cds. U20536 - Human cysteine protease Mch2 isoform alpha (Mch2) mRNA, complete cds. BC000305 - Homo sapiens caspase 6, apoptosis-related cysteine peptidase, mRNA (cDNA clone MGC:8388 IMAGE:2820468), complete cds. BC004460 - Homo sapiens caspase 6, apoptosis-related cysteine peptidase, mRNA (cDNA clone MGC:4318 IMAGE:2820468), complete cds. JD348789 - Sequence 329813 from Patent EP1572962. JD219873 - Sequence 200897 from Patent EP1572962. JD042322 - Sequence 23346 from Patent EP1572962. JD117206 - Sequence 98230 from Patent EP1572962. JD534803 - Sequence 515827 from Patent EP1572962. JD292566 - Sequence 273590 from Patent EP1572962. JD092091 - Sequence 73115 from Patent EP1572962. JD341915 - Sequence 322939 from Patent EP1572962. JD445178 - Sequence 426202 from Patent EP1572962. JD321137 - Sequence 302161 from Patent EP1572962. JD041396 - Sequence 22420 from Patent EP1572962. JD169377 - Sequence 150401 from Patent EP1572962. JD529242 - Sequence 510266 from Patent EP1572962. JD557391 - Sequence 538415 from Patent EP1572962. JD430210 - Sequence 411234 from Patent EP1572962. JD118455 - Sequence 99479 from Patent EP1572962. JD326827 - Sequence 307851 from Patent EP1572962. JD378189 - Sequence 359213 from Patent EP1572962. JD455042 - Sequence 436066 from Patent EP1572962. JD478071 - Sequence 459095 from Patent EP1572962. JD407220 - Sequence 388244 from Patent EP1572962. JD111762 - Sequence 92786 from Patent EP1572962. JD264151 - Sequence 245175 from Patent EP1572962. JD420136 - Sequence 401160 from Patent EP1572962. JD105305 - Sequence 86329 from Patent EP1572962. JD180527 - Sequence 161551 from Patent EP1572962. JD144779 - Sequence 125803 from Patent EP1572962. JD434174 - Sequence 415198 from Patent EP1572962. JD269212 - Sequence 250236 from Patent EP1572962. EU176306 - Synthetic construct Homo sapiens clone IMAGE:100006385; FLH176730.01X; RZPDo839E04251D caspase 6, apoptosis-related cysteine peptidase (CASP6) gene, encodes complete protein. KJ890828 - Synthetic construct Homo sapiens clone ccsbBroadEn_00222 CASP6 gene, encodes complete protein. DQ894589 - Synthetic construct Homo sapiens clone IMAGE:100009049; FLH176724.01L; RZPDo839G08121D caspase 6, apoptosis-related cysteine peptidase (CASP6) gene, encodes complete protein. AB590350 - Synthetic construct DNA, clone: pFN21AE1445, Homo sapiens CASP6 gene for caspase 6, apoptosis-related cysteine peptidase, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors h_mitochondriaPathway - Role of Mitochondria in Apoptotic Signaling h_caspasePathway - Caspase Cascade in Apoptosis h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF h_chemicalPathway - Apoptotic Signaling in Response to DNA Damage h_fasPathway - FAS signaling pathway ( CD95 )
Reactome (by CSHL, EBI, and GO)
Protein P55212 (Reactome details) participates in the following event(s):
R-HSA-350318 Caspase-mediated cleavage of vimentin at TNLD (429) R-HSA-264865 Caspase-mediated cleavage of Lamin A R-HSA-264871 Caspase-mediated cleavage of Lamin B1 R-HSA-352268 Cleavage of Satb1 R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes R-HSA-352238 Breakdown of the nuclear lamina R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-111465 Apoptotic cleavage of cellular proteins R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins R-HSA-212436 Generic Transcription Pathway R-HSA-75153 Apoptotic execution phase R-HSA-73857 RNA Polymerase II Transcription R-HSA-109581 Apoptosis R-HSA-74160 Gene expression (Transcription) R-HSA-5357801 Programmed Cell Death
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
