ID:CASP4_HUMAN DESCRIPTION: RecName: Full=Caspase-4; Short=CASP-4; EC=3.4.22.57; AltName: Full=ICE(rel)-II; AltName: Full=Protease ICH-2; AltName: Full=Protease TX; Contains: RecName: Full=Caspase-4 subunit 1; Contains: RecName: Full=Caspase-4 subunit 2; Flags: Precursor; FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. CATALYTIC ACTIVITY: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-. SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit (By similarity). TISSUE SPECIFICITY: Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain. PTM: The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8. SIMILARITY: Belongs to the peptidase C14A family. SIMILARITY: Contains 1 CARD domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp4/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47986 - DEATH domain 52129 - Caspase-like
ModBase Predicted Comparative 3D Structure on P49662
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
