ID:CATIN_HUMAN DESCRIPTION: RecName: Full=Cactin; AltName: Full=Renal carcinoma antigen NY-REN-24; FUNCTION: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing. SUBUNIT: Interacts (via N-terminus domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent manner. Does not interact with RELA NF-kappa-B subunit. Identified in the spliceosome C complex. SUBCELLULAR LOCATION: Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus. MISCELLANEOUS: Antigen recognized by autologous antibody in patients with renal-cell carcinoma. SIMILARITY: Belongs to the CACTIN family. CAUTION: An ORF (C19orf029 OS) has been described in the opposite strand of the C-terminus of this gene. SEQUENCE CAUTION: Sequence=AAC24305.1; Type=Erroneous gene model prediction; Sequence=AAC32903.1; Type=Erroneous gene model prediction; Sequence=AAD42868.1; Type=Frameshift; Positions=711; Sequence=AAH04262.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW69298.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09732 - Cactus-binding C-terminus of cactin protein PF10312 - Conserved mid region of cactin
ModBase Predicted Comparative 3D Structure on Q8WUQ7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000398 mRNA splicing, via spliceosome GO:0001933 negative regulation of protein phosphorylation GO:0002376 immune system process GO:0006397 mRNA processing GO:0007275 multicellular organism development GO:0008380 RNA splicing GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0032688 negative regulation of interferon-beta production GO:0032717 negative regulation of interleukin-8 production GO:0032720 negative regulation of tumor necrosis factor production GO:0034122 negative regulation of toll-like receptor signaling pathway GO:0045087 innate immune response GO:0060339 negative regulation of type I interferon-mediated signaling pathway GO:0071222 cellular response to lipopolysaccharide GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
