ID:BRMS1_HUMAN DESCRIPTION: RecName: Full=Breast cancer metastasis-suppressor 1; FUNCTION: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. SUBUNIT: Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. INTERACTION: O75190:DNAJB6; NbExp=2; IntAct=EBI-714781, EBI-1053164; Q13547:HDAC1; NbExp=3; IntAct=EBI-714781, EBI-301834; Q92769:HDAC2; NbExp=3; IntAct=EBI-714781, EBI-301821; P56524:HDAC4; NbExp=2; IntAct=EBI-714781, EBI-308629; Q9UQL6:HDAC5; NbExp=2; IntAct=EBI-714781, EBI-715576; Q9UBN7:HDAC6; NbExp=2; IntAct=EBI-714781, EBI-301697; Q13287:NMI; NbExp=2; IntAct=EBI-714781, EBI-372942; Q969G3:SMARCE1; NbExp=2; IntAct=EBI-714781, EBI-455078; Q9H7L9:SUDS3; NbExp=2; IntAct=EBI-714781, EBI-540496; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear. TISSUE SPECIFICITY: Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies. SIMILARITY: Belongs to the BRMS1 family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/BRMS1ID841ch11q13.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCU9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006915 apoptotic process GO:0016575 histone deacetylation GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0042981 regulation of apoptotic process GO:0045892 negative regulation of transcription, DNA-templated GO:0090312 positive regulation of protein deacetylation GO:2000210 positive regulation of anoikis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
