ID:SEC20_HUMAN DESCRIPTION: RecName: Full=Vesicle transport protein SEC20; AltName: Full=BCL2/adenovirus E1B 19 kDa protein-interacting protein 1; AltName: Full=Transformation-related gene 8 protein; Short=TRG-8; FUNCTION: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy. SUBUNIT: Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B 19 kDa protein. SUBCELLULAR LOCATION: Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. TISSUE SPECIFICITY: Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine. PTM: 'Lys-63'-linked polyubiquitination by RNF185 allows recruiting of autophagy receptor SQSTM1, which simultaneously binds both ubiquitin and LC3 to link ubiquitination and autophagy. MISCELLANEOUS: Silencing of BNIP1 disrupts ER morphology. SIMILARITY: Belongs to the SEC20 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bnip1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12981
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ890776 - Synthetic construct Homo sapiens clone ccsbBroadEn_00170 BNIP1 gene, encodes complete protein. HQ448190 - Synthetic construct Homo sapiens clone IMAGE:100071586; CCSB006291_03 BCL2/adenovirus E1B 19kDa interacting protein 1 (BNIP1) gene, encodes complete protein. BC010959 - Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 1, mRNA (cDNA clone MGC:13644 IMAGE:4052817), complete cds. U15172 - Homo sapiens BCL2/adenovirus E1B 19kD-interacting protein 1 (BNIP1) mRNA, complete cds. AF083957 - Homo sapiens Nip1 isoform s2 mRNA, complete cds. AF083958 - Homo sapiens Nip1 isoform s3 mRNA, complete cds. AB527856 - Synthetic construct DNA, clone: pF1KB6379, Homo sapiens BNIP1 gene for BCL2/adenovirus E1B 19kDa interacting protein 1, without stop codon, in Flexi system. CU679862 - Synthetic construct Homo sapiens gateway clone IMAGE:100023315 5' read BNIP1 mRNA. AY216799 - Homo sapiens transformation-related gene 8 mRNA, complete cds. AF083956 - Homo sapiens Nip1 isoform s1 mRNA, complete cds. JD109581 - Sequence 90605 from Patent EP1572962. JD341918 - Sequence 322942 from Patent EP1572962. JD129960 - Sequence 110984 from Patent EP1572962. JD453726 - Sequence 434750 from Patent EP1572962. JD290680 - Sequence 271704 from Patent EP1572962. JD534040 - Sequence 515064 from Patent EP1572962. JD471220 - Sequence 452244 from Patent EP1572962. JD452507 - Sequence 433531 from Patent EP1572962. JD101347 - Sequence 82371 from Patent EP1572962. JD540495 - Sequence 521519 from Patent EP1572962. JD518353 - Sequence 499377 from Patent EP1572962. JD230488 - Sequence 211512 from Patent EP1572962. JD086619 - Sequence 67643 from Patent EP1572962. JD527303 - Sequence 508327 from Patent EP1572962. JD445360 - Sequence 426384 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q12981 (Reactome details) participates in the following event(s):
R-HSA-6811422 NSF ATPase activity dissociates cis-SNARE at the ER R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
