ID:BCL6_HUMAN DESCRIPTION: RecName: Full=B-cell lymphoma 6 protein; Short=BCL-6; AltName: Full=B-cell lymphoma 5 protein; Short=BCL-5; AltName: Full=Protein LAZ-3; AltName: Full=Zinc finger and BTB domain-containing protein 27; AltName: Full=Zinc finger protein 51; FUNCTION: Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis. SUBUNIT: Homodimer. Interacts (via BTB domain) with BCOR; the interaction is direct. Interacts (via BTB domain) with NCOR2; the interaction is direct. Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9. INTERACTION: P56524:HDAC4; NbExp=3; IntAct=EBI-765407, EBI-308629; Q9UKV0:HDAC9; NbExp=2; IntAct=EBI-765407, EBI-765444; Q9ULU4:ZMYND8; NbExp=3; IntAct=EBI-765407, EBI-765834; SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in germinal center T and B-cells and in primary immature dendritic cells. INDUCTION: Down-regulated during maturation of dendritic cells by selective stimuli such as bacterial lipopolysaccharides (LPS), CD40LG and zymosan. DOMAIN: The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2. PTM: Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylation induces its degradation by ubiquitin/proteasome pathway. PTM: Polyubiquitinated. Polyubiquitination leads to degradation by the proteasome. DISEASE: Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. DISEASE: Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. DISEASE: Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 6 C2H2-type zinc fingers. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BCL6ID20.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P41182
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001161 intronic transcription regulatory region sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0031490 chromatin DNA binding GO:0042802 identical protein binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000060 protein import into nucleus, translocation GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000902 cell morphogenesis GO:0001953 negative regulation of cell-matrix adhesion GO:0002376 immune system process GO:0002467 germinal center formation GO:0002634 regulation of germinal center formation GO:0002829 negative regulation of type 2 immune response GO:0002903 negative regulation of B cell apoptotic process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006954 inflammatory response GO:0006974 cellular response to DNA damage stimulus GO:0007266 Rho protein signal transduction GO:0007283 spermatogenesis GO:0008104 protein localization GO:0008285 negative regulation of cell proliferation GO:0019221 cytokine-mediated signaling pathway GO:0030036 actin cytoskeleton organization GO:0030183 B cell differentiation GO:0030308 negative regulation of cell growth GO:0030890 positive regulation of B cell proliferation GO:0031065 positive regulation of histone deacetylation GO:0032764 negative regulation of mast cell cytokine production GO:0035024 negative regulation of Rho protein signal transduction GO:0042092 type 2 immune response GO:0042127 regulation of cell proliferation GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043087 regulation of GTPase activity GO:0043380 regulation of memory T cell differentiation GO:0045591 positive regulation of regulatory T cell differentiation GO:0045596 negative regulation of cell differentiation GO:0045629 negative regulation of T-helper 2 cell differentiation GO:0045666 positive regulation of neuron differentiation GO:0045746 negative regulation of Notch signaling pathway GO:0045892 negative regulation of transcription, DNA-templated GO:0048294 negative regulation of isotype switching to IgE isotypes GO:0048821 erythrocyte development GO:0050727 regulation of inflammatory response GO:0050776 regulation of immune response GO:0051272 positive regulation of cellular component movement GO:1903464 negative regulation of mitotic cell cycle DNA replication GO:2000773 negative regulation of cellular senescence
BC142705 - Homo sapiens B-cell CLL/lymphoma 6, mRNA (cDNA clone MGC:165045 IMAGE:40148809), complete cds. BC150184 - Homo sapiens B-cell CLL/lymphoma 6, mRNA (cDNA clone MGC:164962 IMAGE:40148297), complete cds. BC146796 - Homo sapiens cDNA clone IMAGE:8860299, containing frame-shift errors. U00115 - Human zinc-finger protein (bcl-6) mRNA, complete cds. BX649185 - Homo sapiens mRNA; cDNA DKFZp686M22130 (from clone DKFZp686M22130). JD394639 - Sequence 375663 from Patent EP1572962. JD325081 - Sequence 306105 from Patent EP1572962. JD058934 - Sequence 39958 from Patent EP1572962. JD524955 - Sequence 505979 from Patent EP1572962. JD566171 - Sequence 547195 from Patent EP1572962. JD276886 - Sequence 257910 from Patent EP1572962. JD561195 - Sequence 542219 from Patent EP1572962. JD048679 - Sequence 29703 from Patent EP1572962. Z21943 - H.sapiens mRNA for zinc finger protein. JD053070 - Sequence 34094 from Patent EP1572962. JD277183 - Sequence 258207 from Patent EP1572962. JD426389 - Sequence 407413 from Patent EP1572962. AK304325 - Homo sapiens cDNA FLJ60220 complete cds, highly similar to B-cell lymphoma 6 protein. JD088782 - Sequence 69806 from Patent EP1572962. AK308162 - Homo sapiens cDNA, FLJ98110. JD386449 - Sequence 367473 from Patent EP1572962. JD249111 - Sequence 230135 from Patent EP1572962. S67779 - BCL5=Cys2-His2 zinc-finger transcription factor [human, liver, mRNA, 2600 nt]. JD355294 - Sequence 336318 from Patent EP1572962. EU139066 - Homo sapiens B-cell lymphoma 6 protein transcript variant (BCL6) mRNA, complete cds. EU883531 - Homo sapiens zinc finger transcription factor BCL6S (BCL6) mRNA, complete cds, alternatively spliced. KJ896488 - Synthetic construct Homo sapiens clone ccsbBroadEn_05882 BCL6 gene, encodes complete protein. KJ905147 - Synthetic construct Homo sapiens clone ccsbBroadEn_14547 BCL6 gene, encodes complete protein. AB384967 - Synthetic construct DNA, clone: pF1KB4594, Homo sapiens BCL6 gene for B-cell lymphoma 6 protein, complete cds, without stop codon, in Flexi system. JD501528 - Sequence 482552 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P41182 (Reactome details) participates in the following event(s):
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6785807 Interleukin-4 and 13 signaling R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes R-HSA-449147 Signaling by Interleukins R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-212436 Generic Transcription Pathway R-HSA-168256 Immune System R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
