ID:BAMBI_HUMAN DESCRIPTION: RecName: Full=BMP and activin membrane-bound inhibitor homolog; AltName: Full=Non-metastatic gene A protein; AltName: Full=Putative transmembrane protein NMA; Flags: Precursor; FUNCTION: Negatively regulates TGF-beta signaling. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested. DEVELOPMENTAL STAGE: Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines. SIMILARITY: Belongs to the BAMBI family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13145
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK290639 - Homo sapiens cDNA FLJ75658 complete cds, highly similar to Homo sapiens BMP and activin membrane-bound inhibitor homolog(Xenopus laevis) (BAMBI), mRNA. BC019252 - Homo sapiens BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), mRNA (cDNA clone MGC:1111 IMAGE:3503549), complete cds. AK223065 - Homo sapiens mRNA for BMP and activin membrane-bound inhibitor variant, clone: KAT00534. U23070 - Human putative transmembrane protein (nma) mRNA, complete cds. KJ893463 - Synthetic construct Homo sapiens clone ccsbBroadEn_02857 BAMBI gene, encodes complete protein. AB463445 - Synthetic construct DNA, clone: pF1KB8160, Homo sapiens BAMBI gene for BMP and activin membrane-bound inhibitor homolog, without stop codon, in Flexi system. BT006820 - Homo sapiens putative transmembrane protein mRNA, complete cds. JD056004 - Sequence 37028 from Patent EP1572962. JD197271 - Sequence 178295 from Patent EP1572962. JD507594 - Sequence 488618 from Patent EP1572962. MP015357 - Sequence 560 from Patent WO2019016252. JD291910 - Sequence 272934 from Patent EP1572962. JD260579 - Sequence 241603 from Patent EP1572962. JD233922 - Sequence 214946 from Patent EP1572962. JD111300 - Sequence 92324 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q13145 (Reactome details) participates in the following event(s):
R-HSA-173483 BAMBI interferes with the interaction of type I receptor with type II receptor R-HSA-2173788 Downregulation of TGF-beta receptor signaling R-HSA-2173789 TGF-beta receptor signaling activates SMADs R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-9006936 Signaling by TGF-beta family members R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
