ID:ATP5H_HUMAN DESCRIPTION: RecName: Full=ATP synthase subunit d, mitochondrial; Short=ATPase subunit d; FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane. SIMILARITY: Belongs to the ATPase d subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75947
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006754 ATP biosynthetic process GO:0006811 ion transport GO:0015986 ATP synthesis coupled proton transport GO:0042407 cristae formation GO:0042776 mitochondrial ATP synthesis coupled proton transport GO:0099132 ATP hydrolysis coupled cation transmembrane transport
AK095671 - Homo sapiens cDNA FLJ38352 fis, clone FEBRA1000148. AF070650 - Homo sapiens F1F0-type ATP synthase subunit d mRNA, complete cds. AF087135 - Homo sapiens F1FO-type ATPase subunit d mRNA, nuclear gene encoding mitochondrial protein, complete cds. BC032245 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d, mRNA (cDNA clone MGC:39974 IMAGE:5167128), complete cds. AF061735 - Homo sapiens clone 023e08 My032 protein mRNA, complete cds. AF086159 - Homo sapiens full length insert cDNA clone ZB73B02. BC038092 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d, mRNA (cDNA clone MGC:47701 IMAGE:6020835), complete cds. KJ906044 - Synthetic construct Homo sapiens clone ccsbBroadEn_15714 ATP5H gene, encodes complete protein. AK312230 - Homo sapiens cDNA, FLJ92521, Homo sapiens ATP synthase, H+ transporting, mitochondrial F0complex, subunit d (ATP5H), mRNA. KJ893053 - Synthetic construct Homo sapiens clone ccsbBroadEn_02447 ATP5H gene, encodes complete protein. BC029392 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d, mRNA (cDNA clone IMAGE:4078831), partial cds. DQ583597 - Homo sapiens piRNA piR-50709, complete sequence. JD085757 - Sequence 66781 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7980 - ATP biosynthesis
Reactome (by CSHL, EBI, and GO)
Protein O75947 (Reactome details) participates in the following event(s):
R-HSA-164840 ADP and Pi bind to ATPase R-HSA-8949580 F1Fo ATP synthase dimerizes R-HSA-164834 Enzyme-bound ATP is released R-HSA-164832 ATPase synthesizes ATP R-HSA-163210 Formation of ATP by chemiosmotic coupling R-HSA-8949613 Cristae formation R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1592230 Mitochondrial biogenesis R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
