ID:ATG7_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-like modifier-activating enzyme ATG7; AltName: Full=ATG12-activating enzyme E1 ATG7; AltName: Full=Autophagy-related protein 7; Short=APG7-like; Short=hAGP7; AltName: Full=Ubiquitin-activating enzyme E1-like protein; FUNCTION: Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity). SUBUNIT: Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. INTERACTION: P29692:EEF1D; NbExp=2; IntAct=EBI-987834, EBI-358607; O95166:GABARAP; NbExp=8; IntAct=EBI-987834, EBI-712001; Q9H0R8:GABARAPL1; NbExp=6; IntAct=EBI-987834, EBI-746969; P60520:GABARAPL2; NbExp=4; IntAct=EBI-987834, EBI-720116; P14316:IRF2; NbExp=2; IntAct=EBI-987834, EBI-2866589; Q9GZQ8:MAP1LC3B; NbExp=7; IntAct=EBI-987834, EBI-373144; SUBCELLULAR LOCATION: Cytoplasm (Probable). TISSUE SPECIFICITY: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. DOMAIN: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 (By similarity). SIMILARITY: Belongs to the ATG7 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 69572 - Activating enzymes of the ubiquitin-like proteins 51735 - NAD(P)-binding Rossmann-fold domains
ModBase Predicted Comparative 3D Structure on O95352
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004839 ubiquitin activating enzyme activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0008641 small protein activating enzyme activity GO:0019778 Atg12 activating enzyme activity GO:0019779 Atg8 activating enzyme activity GO:0042803 protein homodimerization activity
Biological Process: GO:0000045 autophagosome assembly GO:0000422 mitophagy GO:0006464 cellular protein modification process GO:0006497 protein lipidation GO:0006501 C-terminal protein lipidation GO:0006914 autophagy GO:0006995 cellular response to nitrogen starvation GO:0007568 aging GO:0009267 cellular response to starvation GO:0009749 response to glucose GO:0010508 positive regulation of autophagy GO:0015031 protein transport GO:0016236 macroautophagy GO:0016567 protein ubiquitination GO:0031401 positive regulation of protein modification process GO:0031667 response to nutrient levels GO:0034727 piecemeal microautophagy of nucleus GO:0039521 suppression by virus of host autophagy GO:0043065 positive regulation of apoptotic process GO:0043312 neutrophil degranulation GO:0044805 late nucleophagy GO:0045732 positive regulation of protein catabolic process GO:0051607 defense response to virus GO:0060548 negative regulation of cell death GO:0061025 membrane fusion GO:0071315 cellular response to morphine GO:0071455 cellular response to hyperoxia GO:0075044 autophagy of host cells involved in interaction with symbiont GO:0090298 negative regulation of mitochondrial DNA replication GO:1901214 regulation of neuron death GO:1902617 response to fluoride GO:1903204 negative regulation of oxidative stress-induced neuron death
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
