ID:ATG13_HUMAN DESCRIPTION: RecName: Full=Autophagy-related protein 13; FUNCTION: Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. SUBUNIT: Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 (via C-terminus). Interacts with ULK2 (via C-terminus). INTERACTION: Q9BSB4:ATG101; NbExp=4; IntAct=EBI-2798775, EBI-2946739; Q9H0R8:GABARAPL1; NbExp=2; IntAct=EBI-2798775, EBI-746969; P60520:GABARAPL2; NbExp=2; IntAct=EBI-2798775, EBI-720116; Q9GZQ8:MAP1LC3B; NbExp=2; IntAct=EBI-2798775, EBI-373144; Q8TDY2:RB1CC1; NbExp=5; IntAct=EBI-2798775, EBI-1047793; SUBCELLULAR LOCATION: Cytoplasm, cytosol (By similarity). Preautophagosomal structure (By similarity). Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation (By similarity). PTM: Phosphorylated by ULK1 and ULK2. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin (By similarity). SIMILARITY: Belongs to the ATG13 metazoan family. SEQUENCE CAUTION: Sequence=BAA31627.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10033 - Autophagy-related protein 13
ModBase Predicted Comparative 3D Structure on O75143
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
