ID:ASPH_HUMAN DESCRIPTION: RecName: Full=Aspartyl/asparaginyl beta-hydroxylase; EC=1.14.11.16; AltName: Full=Aspartate beta-hydroxylase; Short=ASP beta-hydroxylase; AltName: Full=Peptide-aspartate beta-dioxygenase; FUNCTION: Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. FUNCTION: Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. CATALYTIC ACTIVITY: Peptide L-aspartate + 2-oxoglutarate + O(2) = peptide 3-hydroxy-L-aspartate + succinate + CO(2). COFACTOR: Iron. SUBUNIT: Monomer (By similarity). Isoform 8 interacts with ORAI1 and STIM1. SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: Isoform 8: Endoplasmic reticulum membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level). SIMILARITY: Belongs to the aspartyl/asparaginyl beta-hydroxylase family. SIMILARITY: Contains 4 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12797
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005513 detection of calcium ion GO:0006936 muscle contraction GO:0007389 pattern specification process GO:0008285 negative regulation of cell proliferation GO:0010524 positive regulation of calcium ion transport into cytosol GO:0010649 regulation of cell communication by electrical coupling GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0018193 peptidyl-amino acid modification GO:0022900 electron transport chain GO:0031585 regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0031647 regulation of protein stability GO:0032237 activation of store-operated calcium channel activity GO:0033198 response to ATP GO:0034220 ion transmembrane transport GO:0035108 limb morphogenesis GO:0042264 peptidyl-aspartic acid hydroxylation GO:0045862 positive regulation of proteolysis GO:0045893 positive regulation of transcription, DNA-templated GO:0055114 oxidation-reduction process GO:0060021 palate development GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060325 face morphogenesis GO:0070588 calcium ion transmembrane transport GO:0071277 cellular response to calcium ion GO:0090316 positive regulation of intracellular protein transport GO:0097202 activation of cysteine-type endopeptidase activity GO:1901879 regulation of protein depolymerization GO:1903779 regulation of cardiac conduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
