ID:ABC3C_HUMAN DESCRIPTION: RecName: Full=Probable DNA dC->dU-editing enzyme APOBEC-3C; EC=3.5.4.-; AltName: Full=APOBEC1-like; AltName: Full=Phorbolin I; FUNCTION: Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3). COFACTOR: Zinc (By similarity). SUBUNIT: Interacts with human foamy virus protein Bet; this interaction does not induce APOBEC3C degradation, but prevents dimerization and incorporation into virion of the latter. TISSUE SPECIFICITY: Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary. MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase family. SEQUENCE CAUTION: Sequence=AAF86650.1; Type=Frameshift; Positions=172;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NRW3
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003723 RNA binding GO:0003824 catalytic activity GO:0005515 protein binding GO:0008270 zinc ion binding GO:0016787 hydrolase activity GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0046872 metal ion binding
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
