ID:ADCY2_HUMAN DESCRIPTION: RecName: Full=Adenylate cyclase type 2; EC=4.6.1.1; AltName: Full=ATP pyrophosphate-lyase 2; AltName: Full=Adenylate cyclase type II; AltName: Full=Adenylyl cyclase 2; FUNCTION: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. CATALYTIC ACTIVITY: ATP = 3',5'-cyclic AMP + diphosphate. COFACTOR: Binds 2 magnesium ions per subunit (By similarity). ENZYME REGULATION: Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation. SUBUNIT: Interacts with RAF1. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in brain. PTM: Phosphorylated by RAF1. SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. SIMILARITY: Contains 2 guanylate cyclase domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08462
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF410885 - Homo sapiens adenylyl cyclase type II mRNA, complete cds. AK127036 - Homo sapiens cDNA FLJ45092 fis, clone BRAWH3029806, highly similar to Adenylate cyclase, type II (EC 4.6.1.1). KJ896378 - Synthetic construct Homo sapiens clone ccsbBroadEn_05772 ADCY2 gene, encodes complete protein. BC111743 - Homo sapiens adenylate cyclase 2 (brain), mRNA (cDNA clone MGC:133314 IMAGE:40038765), complete cds. AK304041 - Homo sapiens cDNA FLJ61534 complete cds, highly similar to Adenylate cyclase type 2 (EC 4.6.1.1). AK299775 - Homo sapiens cDNA FLJ54510 complete cds, highly similar to Adenylate cyclase type 2 (EC 4.6.1.1). AK123013 - Homo sapiens cDNA FLJ16822 fis, clone TRACH3030111, highly similar to Adenylate cyclase type 2 (EC 4.6.1.1). AB028983 - Homo sapiens mRNA for KIAA1060 protein, partial cds. AK294555 - Homo sapiens cDNA FLJ58757 complete cds, highly similar to Adenylate cyclase type 2 (EC 4.6.1.1). AK295531 - Homo sapiens cDNA FLJ60265 complete cds, highly similar to Adenylate cyclase type 2 (EC 4.6.1.1). L21993 - Human adenylyl cyclase mRNA, 3' end of cds. X74210 - H.sapiens mRNA for adenylyl cyclase. AF070583 - Homo sapiens clone 24648 adenylyl cyclase mRNA, partial cds. AK307474 - Homo sapiens cDNA, FLJ97422. CR749634 - Homo sapiens mRNA; cDNA DKFZp686J099 (from clone DKFZp686J099). JD297563 - Sequence 278587 from Patent EP1572962. JD316449 - Sequence 297473 from Patent EP1572962. JD101758 - Sequence 82782 from Patent EP1572962. JD527664 - Sequence 508688 from Patent EP1572962. JD565887 - Sequence 546911 from Patent EP1572962. JD500840 - Sequence 481864 from Patent EP1572962. JD522899 - Sequence 503923 from Patent EP1572962. JD454815 - Sequence 435839 from Patent EP1572962. JD547915 - Sequence 528939 from Patent EP1572962. JD186744 - Sequence 167768 from Patent EP1572962. JD037366 - Sequence 18390 from Patent EP1572962. JD236369 - Sequence 217393 from Patent EP1572962. JD506697 - Sequence 487721 from Patent EP1572962. JD285627 - Sequence 266651 from Patent EP1572962. JD095979 - Sequence 77003 from Patent EP1572962. JD195169 - Sequence 176193 from Patent EP1572962. JD502578 - Sequence 483602 from Patent EP1572962. JD288463 - Sequence 269487 from Patent EP1572962. JD100797 - Sequence 81821 from Patent EP1572962. JD310827 - Sequence 291851 from Patent EP1572962. JD359842 - Sequence 340866 from Patent EP1572962. JD348068 - Sequence 329092 from Patent EP1572962. JD240186 - Sequence 221210 from Patent EP1572962. JD332118 - Sequence 313142 from Patent EP1572962. JD494912 - Sequence 475936 from Patent EP1572962. JD290017 - Sequence 271041 from Patent EP1572962. JD260505 - Sequence 241529 from Patent EP1572962. JD267303 - Sequence 248327 from Patent EP1572962. JD300740 - Sequence 281764 from Patent EP1572962. JD073374 - Sequence 54398 from Patent EP1572962. JD483153 - Sequence 464177 from Patent EP1572962. JD181385 - Sequence 162409 from Patent EP1572962. JD455448 - Sequence 436472 from Patent EP1572962. JD500484 - Sequence 481508 from Patent EP1572962. JD301394 - Sequence 282418 from Patent EP1572962. JD137210 - Sequence 118234 from Patent EP1572962. JD285371 - Sequence 266395 from Patent EP1572962. JD070710 - Sequence 51734 from Patent EP1572962. JD221336 - Sequence 202360 from Patent EP1572962. JD229757 - Sequence 210781 from Patent EP1572962. JD300946 - Sequence 281970 from Patent EP1572962. JD481360 - Sequence 462384 from Patent EP1572962. JD138722 - Sequence 119746 from Patent EP1572962. JD428968 - Sequence 409992 from Patent EP1572962. JD284676 - Sequence 265700 from Patent EP1572962. JD310152 - Sequence 291176 from Patent EP1572962. JD558783 - Sequence 539807 from Patent EP1572962. JD442984 - Sequence 424008 from Patent EP1572962. JD118501 - Sequence 99525 from Patent EP1572962. JD118500 - Sequence 99524 from Patent EP1572962. JD340547 - Sequence 321571 from Patent EP1572962. JD340546 - Sequence 321570 from Patent EP1572962. JD082667 - Sequence 63691 from Patent EP1572962. JD058304 - Sequence 39328 from Patent EP1572962. JD144135 - Sequence 125159 from Patent EP1572962. JD090429 - Sequence 71453 from Patent EP1572962. JD282203 - Sequence 263227 from Patent EP1572962. JD097682 - Sequence 78706 from Patent EP1572962. JD136100 - Sequence 117124 from Patent EP1572962. JD136101 - Sequence 117125 from Patent EP1572962. JD243165 - Sequence 224189 from Patent EP1572962. JD238308 - Sequence 219332 from Patent EP1572962. JD430902 - Sequence 411926 from Patent EP1572962. JD443825 - Sequence 424849 from Patent EP1572962. JD071450 - Sequence 52474 from Patent EP1572962. JD431380 - Sequence 412404 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q08462 (Reactome details) participates in the following event(s):
R-HSA-163617 G alpha (s) activates adenylate cyclase R-HSA-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it R-HSA-392064 G alpha (z) inhibits adenylate cyclase R-HSA-392206 G alpha (i) inhibits adenylate cyclase R-HSA-170674 Dissociation of the Gi alpha:G olf complex R-HSA-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates R-HSA-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex R-HSA-111930 Adenylate cyclase produces cAMP R-HSA-392129 Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate R-HSA-5610727 GPR161 promotes cAMP production in a G alpha(s)-dependent manner R-HSA-164377 Activated Adenylate cyclase catalyses cAMP synthesis R-HSA-170676 Adenylate cyclase converts ATP into cyclic AMP R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf R-HSA-163359 Glucagon signaling in metabolic regulation R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-170660 Adenylate cyclase activating pathway R-HSA-418597 G alpha (z) signalling events R-HSA-170670 Adenylate cyclase inhibitory pathway R-HSA-418594 G alpha (i) signalling events R-HSA-163685 Energy Metabolism R-HSA-388396 GPCR downstream signalling R-HSA-445717 Aquaporin-mediated transport R-HSA-112040 G-protein mediated events R-HSA-997269 Inhibition of adenylate cyclase pathway R-HSA-163615 PKA activation R-HSA-5610787 Hedgehog 'off' state R-HSA-164378 PKA activation in glucagon signalling R-HSA-1430728 Metabolism R-HSA-372790 Signaling by GPCR R-HSA-382551 Transport of small molecules R-HSA-111885 Opioid Signalling R-HSA-991365 Activation of GABAB receptors R-HSA-111931 PKA-mediated phosphorylation of CREB R-HSA-5358351 Signaling by Hedgehog R-HSA-162582 Signal Transduction R-HSA-977444 GABA B receptor activation R-HSA-111933 Calmodulin induced events R-HSA-977443 GABA receptor activation R-HSA-111997 CaM pathway R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-111996 Ca-dependent events R-HSA-1489509 DAG and IP3 signaling R-HSA-112315 Transmission across Chemical Synapses R-HSA-112043 PLC beta mediated events R-HSA-9006925 Intracellular signaling by second messengers R-HSA-112316 Neuronal System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
