ID:AATF_HUMAN DESCRIPTION: RecName: Full=Protein AATF; AltName: Full=Apoptosis-antagonizing transcription factor; AltName: Full=Rb-binding protein Che-1; FUNCTION: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. SUBUNIT: Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT. INTERACTION: Q13315:ATM; NbExp=3; IntAct=EBI-372428, EBI-495465; O96017:CHEK2; NbExp=4; IntAct=EBI-372428, EBI-1180783; Q04206:RELA; NbExp=3; IntAct=EBI-372428, EBI-73886; SUBCELLULAR LOCATION: Nucleus, nucleolus. TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus. PTM: Hyperphosphorylated during the G1/S phase transition. SIMILARITY: Belongs to the AATF family. SEQUENCE CAUTION: Sequence=AAD52016.1; Type=Frameshift; Positions=355, 365, 487, 498, 503; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/AATFID534ch17q11.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NY61
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003723 RNA binding GO:0005515 protein binding GO:0019904 protein domain specific binding GO:0043522 leucine zipper domain binding GO:0048156 tau protein binding
Biological Process: GO:0006974 cellular response to DNA damage stimulus GO:0007155 cell adhesion GO:0007346 regulation of mitotic cell cycle GO:0032929 negative regulation of superoxide anion generation GO:0040016 embryonic cleavage GO:0042254 ribosome biogenesis GO:0042985 negative regulation of amyloid precursor protein biosynthetic process GO:0043066 negative regulation of apoptotic process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:2000378 negative regulation of reactive oxygen species metabolic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
