IRF3 |
Rabbit polyclonal. Epitope corresponding to amino acids 1-425 of IRF-3 of human origin. Antibody Target: IRF3 |
IRF3 |
Mediates interferon-stimulated response element (ISRE) promoter activation. DsRNA leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. |
Santa Cruz Biotechnology sc-9082 |
Snyder |
Human - IRF3(Immunoblot)
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GeneCard:IRF3 |
IRF3 (sc-9082) |